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Le T Duong Selected Research

Cathepsin K

1/2021Preclinical evaluation of [11 C]L-235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone.
1/2020Effects of Odanacatib on Bone Structure and Quality in Postmenopausal Women With Osteoporosis: 5-Year Data From the Phase 3 Long-Term Odanacatib Fracture Trial (LOFT) and its Extension.
11/2018Articular cartilage protection in Ctsk-/- mice is associated with cellular and molecular changes in subchondral bone and cartilage matrix.
7/2017Cathepsin K Controls Cortical Bone Formation by Degrading Periostin.
12/2016Odanacatib, effects of 16-month treatment and discontinuation of therapy on bone mass, turnover and strength in the ovariectomized rabbit model of osteopenia.
4/2016Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.
4/2016Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.
12/2014Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis.
8/2014Altered hematopoietic stem cell and osteoclast precursor frequency in cathepsin K null mice.
8/2014Chondroitin sulfate promotes activation of cathepsin K.
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Le T Duong Research Topics

Disease

23Bone Resorption
12/2018 - 05/2002
14Osteoporosis
01/2021 - 09/2004
4Osteoarthritis
06/2012 - 10/2003
3Postmenopausal Osteoporosis
06/2017 - 01/2012
3Disease Progression
10/2013 - 09/2007
3Osteophyte
08/2011 - 04/2004
2Metabolic Bone Diseases (Osteopenia)
12/2016 - 08/2011
2Neoplasm Metastasis (Metastasis)
06/2015 - 12/2014
2Neoplasms (Cancer)
06/2015 - 12/2014
1Pycnodysostosis
11/2018
1Weight Loss (Weight Reduction)
06/2015
1Melanoma (Melanoma, Malignant)
06/2015
1Breast Neoplasms (Breast Cancer)
12/2014
1Femoral Fractures (Femoral Fracture)
07/2013
1Sclerosis
08/2011
1Periodontal Diseases (Periodontal Disease)
01/2007
1Bone Diseases (Bone Disease)
01/2007
1Rheumatoid Arthritis
01/2007

Drug/Important Bio-Agent (IBA)

17Cathepsin KIBA
01/2021 - 02/2011
10odanacatibIBA
01/2020 - 01/2012
6Alendronate (Alendronate Sodium)FDA LinkGeneric
12/2018 - 04/2004
5Peptides (Polypeptides)IBA
04/2017 - 01/2003
3Diphosphonates (Bisphosphonates)IBA
12/2018 - 12/2013
3Pharmaceutical PreparationsIBA
06/2017 - 03/2012
3IntegrinsIBA
06/2015 - 01/2003
2EnzymesIBA
01/2021 - 12/2013
2Biomarkers (Surrogate Marker)IBA
04/2017 - 04/2016
2Collagen Type I (Type I Collagen)IBA
04/2017 - 06/2012
2CRA 013783IBA
12/2013 - 06/2012
2Blocking AntibodiesIBA
01/2007 - 01/2003
2Integrin beta3 (GPIIIa)IBA
01/2007 - 01/2003
1Parathyroid Hormone (Parathormone)IBA
12/2018
1MineralsIBA
12/2018
1relacatibIBA
04/2016
1ONO-5334IBA
04/2016
1balicatibIBA
04/2016
1Tartrate-Resistant Acid PhosphataseIBA
04/2016
1Protein Isoforms (Isoforms)IBA
04/2016
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2015
1LuciferasesIBA
06/2015
13- (6- methoxypyridin- 3- yl)- 3- (2- oxo- 3- (3- (5,6,7,8- tetrahydro(1,8)naphthyridin- 2- yl)propyl)imidazolidin- 1- yl)propionic acidIBA
06/2015
1Messenger RNA (mRNA)IBA
12/2014
1Zoledronic Acid (Zometa)FDA Link
12/2014
1Proteins (Proteins, Gene)FDA Link
12/2014
1Collagenases (Collagenase)FDA Link
08/2014
1Cysteine Proteases (Cysteine Protease)IBA
08/2014
1Bone Density Conservation AgentsIBA
01/2014
1CollagenIBA
12/2013
1L-873724IBA
12/2013
1N- (cyanomethyl)- 4- methyl- 2- (4'- (1- piperazinyl)(1,1'- biphenyl)- 3- yl)pentanamideIBA
12/2013
1CytokinesIBA
12/2012
1collagen type I trimeric cross-linked peptideIBA
06/2012
1ElementsIBA
06/2012
1Collagen Type II (Type II Collagen)IBA
06/2012
1Estrogens (Estrogen)FDA Link
03/2012
1Biological ProductsIBA
09/2007
1PPAR gammaIBA
09/2007
1PPAR alphaIBA
09/2007
1arginyl-glycyl-aspartic acidIBA
01/2007
1Dihydrotachysterol (AT 10)IBA
02/2006
1Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
10/2003
1Phosphotransferases (Kinase)IBA
03/2003
1TNF Receptor-Associated Factor 6 (TRAF6)IBA
05/2002

Therapy/Procedure

5Therapeutics
12/2016 - 01/2007
1Euthanasia (Mercy Killing)
07/2013
1Meniscectomy
08/2011
1Oral Administration
09/2004